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Some steroids are made in private labs and are experimental, or a combination of different types of steroids in hopes of further enhancing their effects on muscle growth," said Dr. John Beaulieu, an associate professor of medicine and an endocrinologist at UC Davis (and author of numerous peer-reviewed papers on hormone therapy for men) and chief clinical investigator for the study of testosterone in men. Testosterone plays a large role in male sexual and social development. Without testosterone levels in the male fetus, boys cannot become fully masculinized or mens-hirs of their adult sex. This is a profound effect — the effects of testosterone on the developing body are so drastic that many clinicians believe that if testosterone had been available during the prenatal development of the fetus, it would have altered male sexual development as well. "As early as the 18 months of post-fertilization, testosterone is in the fetus," said Dr. Michael Berenson, director of the National Institute on Drug Abuse at the National Institutes of Health and a member of the study's research arm. "It has an effect on the development of male sexual characteristics." It's one mechanism by which testosterone has been shown to influence sexual development. There are also studies suggesting that testosterone may influence the development of sexual identity — in particular, testosterone may affect the sexual preferences of transgender people, which means that a transgender person may desire to cross-dress or have female-type genitalia. Some researchers have argued that an individual who is transgendered may actually prefer males with male genitals as opposed to female ones because of the way that testosterone influences male sexual development. For some people, however, the effects of testosterone may occur in the opposite way. Dr. Beaulieu said that, in transgender individuals with low testosterone levels but still wanting to grow into their preferred gender, estrogen appears to be helpful. This may happen in part because of differences between the sexes: women may choose to undergo surgery while men might not. There is a lot of evidence, then, about the importance of testosterone for the sexual development of men and the reproductive system in women and children. How testosterone is best used for that is not yet known. In the meantime, Beaulieu said, "it's important that we can better understand how testosterone has effects in people." Similar articles: